The 3RCC will fund four projects that replace, reduce and refine animal experiments with CHF 1.3 million. Researchers at the ETH Zurich will receive a grant to develop tools to analyse the behaviour of laboratory rodents, which will improve animal welfare and reduce animal numbers.
At the University of Bern, the 3RCC will fund three groups developing human-based models to study cancer, lung fibrosis and drug transfer between mother and child. In three of four projects researchers aim to replace approaches using living animals with methods based on cultured patient cells.
Such novel non-animal methods promise to be more reliable, reproducible and relevant to humans. Due to its limited funding budget the 3RCC had to reject many promising proposals for innovative solutions to improve or replace animal experiments.
The Strategic Board has selected four projects that will be financed through its 2019 Open Call:
OC-2019-009: BEHAVE: A toolkit for deep-behavior profiling of laboratory rodents, Johannes Bohacek, Department of Health Sciences and Technology, ETH Zurich
OC-2019-025: IPF-on-Chip: Replacing the bleomycin induced lung injury and fibrosis model with lung-on-chip technology, Olivier Guenat, ARTORG Center for Biomedical Engineering Research, University of Bern; Thomas Geiser, Pneumology Department, Inselspital, Bern University Hospital
OC-2019-003: Development of a platform for GU cancer patient-derived organoids, Marianna Kruithof-de Julio, Mark Rubin, Department for BioMedical Research (DBMR), University of Bern
OC-2019-019: Engineering a novel cell-based model for assessing materno-fetal drug transfer during pregnancy, Christiane Albrecht, Institute of Biochemistry and Molecular Medicine, University of Bern; František Štaud, Pharmaceutical Faculty, Charles University, Hradec Kralove, Czech Republic; Chennakesava Cuddapah, Curio Biotech SA, Visp, Switzerland